As a child, he produced a number of short films on Super 8 and video before beginning his studies as a film director in Munich and Vienna. He also studied literature and economics in Cologne and Siegen. Uwe graduated from university in 1995 with a doctorate in literature. From 1995-2000, he was a producer and director with Taunus Film-Produktions GmbH. Boll is currently Chief Executive Officer of Boll Filmproduction and Distribution GmbH which he founded in 1992. In 2000 he founded Boll KG and continues to direct, write and produce feature films.
All three of the films he's directed that were based upon video games, House of the Dead (2003), Alone in the Dark (2005), and BloodRayne (2005) are listed on the IMDb Bottom 100. The other seven films he's directed, including Heart of America (2003), Blackwoods (2002) and Erste Semester, Das (1997) are not widely available in America, but have received similarly low ratings among those who have seen them.
His favorite video-game is Hitman: Codename 47 (2000) (VG).
His favorite film of 2005 is Sin City.
He is good friends with Clint Howard and cast him in Blackwoods, Heart of America and House of the Dead.